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13456-08-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 13456-08-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,5 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13456-08:
91 % 10 = 1
So 13456-08-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 1-(2-piperidin-1-ylethyl)-3-[(E)-[(3Z)-3-(2-piperidin-1-ylethylcarbamothioylhydrazinylidene)butan-2-ylidene]amino]thiourea

1.2 Other means of identification

Product number -
Other names Bitipazonum

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13456-08-1 SDS

13456-08-1Downstream Products

13456-08-1Relevant articles and documents

Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies

Palma, Elisa,Botelho, Hugo M.,Morais, Goreti Ribeiro,Rodrigues, Inês,Santos, Isabel Cordeiro,Campello, Maria Paula Cabral,Raposinho, Paula,Belchior, Ana,Gomes, Susana Sousa,Araújo, Maria Fátima,Correia, Isabel,Ribeiro, Nadia,Gama, Sofia,Mendes, Filipa,Paulo, António

, p. 71 - 89 (2019)

The development of pharmacologically active compounds based on bis(thiosemicarbazones) (BTSC) and on their coordination to metal centers constitutes a promising field of research. We have recently explored this class of ligands and their Cu(II) complexes for the design of cancer theranostics agents with enhanced uptake by tumoral cells. In the present work, we expand our focus to aliphatic and aromatic BTSC Zn(II) complexes bearing piperidine/morpholine pendant arms. The new complexes ZnL1–ZnL4 were characterized by a variety of analytical techniques, which included single-crystal X-ray crystallography for ZnL2 and ZnL3. Taking advantage of the fluorescent properties of the aromatic complexes, we investigated their cellular uptake kinetics and subcellular localization. Furthermore, we tried to elucidate the mechanism of action of the cytotoxic effect observed in human cancer cell line models. The results show that the aliphatic complexes (ZnL1 and ZnL2) have a symmetrical structure, while the aromatic counterparts (ZnL3 and ZnL4) have an asymmetrical nature. The cytotoxic activity was higher for the aromatic BTSC complexes, as well as the cellular uptake, evaluated by measurement of intracellular Zn accumulation. Among the most active complexes, ZnL3 presented the fastest uptake kinetics and lysosomal localization assessed by live-cell microscopy. Detailed studies of its impact on cellular production of reactive oxygen species and impairment of lysosomal membrane integrity reinforced the influence of the pendant piperidine in the biological performance of aromatic BTSC Zn(II) complexes.

Anticoccidial activity of dithiosemicarbazones


, p. 950 - 967 (2007/10/05)

Dithiosemicarbazones (di-TSC) with one or two basic substituents were found to be highly active against a variety of Eimeria species (coccidia) in chicks after both prophylactic and therapeutic application. As to the structure-activity relation, it could be shown that the necessary prerequisites of activity were a di-TSC structure in which at least one radical of the TSC part of the molecule carried a basic function, and the C=S group in TSC being freely enolizable, i.e., both nitrogen atoms next to the C=S group carrying another hydrogen atom. If the C=S groups were replaced by C=O or C=NH to form either disemicarbazones or diguanylhydrazones, the compounds obtained were ineffective. The limitation of action to di-TSC with basic substituents of a small volume suggested that the basic radical was of great importance for the absorption of the compound by the mucosa and penetration into the coccidia. The activity against coccidia was clearly attributable to the whole molecule, since the parts resulting from degradation (possibly by hydrolysis), e.g., α,β-dicarbonyl compounds and their derivatives, such as dihydrazones or thiosemicarbazides with basic substituents, or isothiocyanates with basic substituents, were completely ineffective.

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