1345669-64-8Relevant articles and documents
Ultrasound promoted the synthesis of N-propargylic β-enaminones
Martins, Marcos A.P.,Rossatto, Marcelo,Prola, Liziê D.T.,Pizzuti, Lucas,Moreira, Dayse N.,Campos, Patrick T.,Frizzo, Clarissa P.,Zanatta, Nilo,Bonacorso, Helio G.
, p. 227 - 231 (2012/04/10)
The synthesis of 14 novel N-propargylic β-enaminones from the reaction of β-alkoxy vinyltrihalomethyl[carboxyethyl] ketones [R 3C(O)CHC(R1)OMe, where R3 = CF3, CCl3, CO2Et and R1 = Me, Et, Pr, Bu, i-Pent, CH2CH2CO2Me] with propargyl amines [R 2NHCH2CCH, where R2 = Pr, PhCH2] is reported. Yields, solvents and reaction times needed for reaction completion, by microwave irradiation (MW), conventional thermal heating (TH) and under ultrasound irradiation (US) are compared. The best results were obtained under US irradiation in good to excellent yields (70-93%).