134567-07-0

Basic information

• Product Name: 5'-O-thymidylyl-4-thiothymidine
• Synonyms: 5'-O-thymidylyl-4-thiothymidine
• CAS NO: 134567-07-0
• Molecular Weight: 562.494
• Mol File: 134567-07-0.mol

Chemical Properties

• CAS DataBase Reference: 5'-O-thymidylyl-4-thiothymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-thymidylyl-4-thiothymidine(134567-07-0)
• EPA Substance Registry System: 5'-O-thymidylyl-4-thiothymidine(134567-07-0)

Safety Data

• Hazardous Substances Data: 134567-07-0(Hazardous Substances Data)

Upstream product

• 7236-57-9 4-thiothymidine 

Relevant articles and documents

Synthesis of Deoxydinucleoside Phosphates Containing 4-Thio Substituted Pyrimidine Nucleobases

The preparations, by the hydrogenphosphonate approach in solution, of the five pyrimidine deoxydinucleoside monophosphates 14a, 14b, 16a, 16b and 17 containing a 4-thiosubstituted pyrimidine nucleobase at either their 3'- or 5'-end are described.These syntheses were conveniently accomplished using 4-thionucleoside derivatives having their sulfur function protected by S-pivaloyloxymethylation.The behaviour of unprotected 4-thionucleoside derivatives was also investigated and they were shown to give comparable overall yields.

Synthesis of Dinucleoside Phosphates Containing Sulfur Substituted Nucleobases: 4-Thiouracil, 4-Thiothymine and 6-Mercaptopurine

S-Pivaloyloxymethylation of sulfur substituted nucleobases enables the synthesis in solution of dinucleoside phosphates containing sulfur modified residues such as 4-thiouracil, 4-thiothymine and 6-mercatopurine. Key words: 4-thiouracil; protection; phosphorylation; nucleosides.