1345691-07-7

Basic information

• Product Name: 2,2'-{[4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarboxamide
• CAS NO: 1345691-07-7
• Molecular Weight: 403.398
• Mol File: 1345691-07-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2'-{[4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-{[4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarboxamide(1345691-07-7)
• EPA Substance Registry System: 2,2'-{[4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarboxamide(1345691-07-7)

Safety Data

• Hazardous Substances Data: 1345691-07-7(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 10354-30-0 4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 4426-72-6 hydrazine carboxamide 

Relevant articles and documents

Synthesis and anticancer activity of some new series of 1, 4-dihydropyridine derivatives

A series of 1,4-dihydropyridine derivatives 1a-c have been prepared from 4-substituted aromatic aldehyde, ethyl acetoacetate and ammonium hydroxide following Hantzsch method. The compounds 1a-c have been reacted with semicarbazide to give the compounds 2a-c. The compounds 1a-c have been reacted with thiosemicarbazide to give the compounds 3a-c. The structures of synthesized compounds are confirmed by IR, 1H and 13C NMR, mass spectrometry and elemental analyses. The newly synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound 2a is highly active against HepG2, MCF-7 and 3a is highly active against Hela (Cervical) and these have been selected for advanced preclinical development.