1345693-29-9

Basic information

• Product Name: 1-[(3-boronophenyl)methyl]-1,4,7,10-tetraazacyclododecane
• CAS NO: 1345693-29-9
• Molecular Weight: 306.216
• Mol File: 1345693-29-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(3-boronophenyl)methyl]-1,4,7,10-tetraazacyclododecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(3-boronophenyl)methyl]-1,4,7,10-tetraazacyclododecane(1345693-29-9)
• EPA Substance Registry System: 1-[(3-boronophenyl)methyl]-1,4,7,10-tetraazacyclododecane(1345693-29-9)

Safety Data

• Hazardous Substances Data: 1345693-29-9(Hazardous Substances Data)

Upstream product

• 1345693-28-8 1-[(3-boronophenyl)methyl]-4,7,10-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 
• 76-05-1 trifluoroacetic acid 
• 175854-39-4 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 
• 294-90-6 1,4,7,10-tetraazacyclododecan 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Boron-Containing Macrocyclic Polyamines and Their Zinc(II) Complexes for Boron Neutron Capture Therapy

Boron neutron capture therapy (BNCT) is a binary therapeutic method for cancer treatment based on the use of a combination of a cancer-specific drug containing boron-10 (10B) and thermal neutron irradiation. For successful BNCT,10B-containing molecules need to accumulate specifically in cancer cells, because destructive effect of the generated heavy particles is limited basically to boron-containing cells. Herein, we report on the design and synthesis of boron compounds that are functionalized with 9-, 12-, and 15-membered macrocyclic polyamines and their Zn2+complexes. Their cytotoxicity, intracellular uptake activity into cancer cells and normal cells, and BNCT effect are also reported. The experimental data suggest that mono- and/or diprotonated forms of metal-free [12]aneN4- and [15]aneN5-type ligands are uptaken into cancer cells, and their complexes with intracellular metals such as Zn2+would induce cell death upon thermal neutron irradiation, possibly via interactions with DNA.