1345693-73-3Relevant academic research and scientific papers
Synthesis of α,α-disubstituted α-amino esters: Nucleophilic addition to iminium salts generated from amino ketene silyl acetals
Hata, Shingo,Koyama, Hiroshi,Shimizu, Makoto
experimental part, p. 9670 - 9677 (2012/01/04)
Alkoxycarbonyl iminium species are prepared easily by the oxidation of tetrasubstituted amino ketene silyl acetals, and subsequent nucleophilic addition of Grignard reagents to the iminium salts gives α,α- disubstituted α-amino ester derivatives in moderate to good yields, in which aryl and ethynyl substituents are readily introduced.
