1345695-50-2

Upstream product

• 1428730-23-7 C₂₃H₁₆F₄N₆O 
• 459-57-4 4-fluorobenzaldehyde 
• 2272-38-0 6-chloro-N,N'-bis-(2,4-difluoro-phenyl)-[1,3,5]triazine-2,4-diamine 

Relevant academic research and scientific papers

Antimicrobial evaluation of some novel isoxazoles, cyanopyridines and pyrimidinthiones

The title compounds 7a-f, 8a-f and 9a-f have been prepared from chalcones 6a-f having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles 7a-f and cyanopyridines 8a-f respectively. Chalcones 6a-f on condensation with thiourea in the presence of alkali give pyrimidinthiones 9a-f. Structures of newly synthesised compound have been established on the basis of their elemental analysis, IR and 1H NMR spectral data. All the synthesised compounds have been screened for their antimicrobial activity.