1345707-97-2Relevant academic research and scientific papers
Novel paramagnetic AT1 receptor antagonists
Tan, Nichole P. H.,Taylor, Michelle K.,Bottle, Steven E.,Wright, Christine E.,Ziogas, James,White, Jonathan M.,Schiesser, Carl H.,Jani, Nitya V.
, p. 12083 - 12085 (2011)
Novel paramagnetic selective angiotensin AT1 receptor antagonists (sartans) bearing nitroxides (3, 4) have been prepared and their pharmacology evaluated in vitro as well as in vivo. Compounds 3, 4 proved to be effective sartans with pKB estimates in the range 6.2-9.1. In addition, the sodium salt (11) of 4 (R = Bu) is able to protect against vascular injury in hypertensive rats as determined by its ability to attenuate the development of intimal thickening caused by balloon injury of the carotid artery. The Royal Society of Chemistry 2011.
