1345719-55-2

Basic information

• Product Name: diethyl ((4-broMophenyl)ethynyl)phosphonate
• Synonyms: diethyl ((4-broMophenyl)ethynyl)phosphonate
• CAS NO: 1345719-55-2
• Molecular Weight: 317.119
• Mol File: 1345719-55-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: diethyl ((4-broMophenyl)ethynyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl ((4-broMophenyl)ethynyl)phosphonate(1345719-55-2)
• EPA Substance Registry System: diethyl ((4-broMophenyl)ethynyl)phosphonate(1345719-55-2)

Safety Data

• Hazardous Substances Data: 1345719-55-2(Hazardous Substances Data)

Usage

Description

Diethyl ((4-bromophenyl)ethynyl)phosphonate is a chemical compound with the molecular formula C12H13BrO2P. It belongs to the class of organophosphorus compounds and is commonly used as a key intermediate in the synthesis of pharmaceutical compounds and agrochemicals.

Uses

Used in Pharmaceutical Industry:
Diethyl ((4-bromophenyl)ethynyl)phosphonate is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block in the development of new drugs.
Used in Agrochemical Industry:
Diethyl ((4-bromophenyl)ethynyl)phosphonate is also used as an intermediate in the synthesis of agrochemicals. Its properties allow for the creation of effective pesticides and other agricultural products.
Safety Precautions:
It is important to handle diethyl ((4-bromophenyl)ethynyl)phosphonate with caution, as it can be harmful if ingested or if it comes into contact with skin or eyes. Additionally, it should be stored in a cool, dry place and handled in a well-ventilated area to avoid potential health hazards.

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 762-04-9 phosphonic acid diethyl ester 
• 934-94-1 1-bromo-4-bromoethynyl-benzene 
• 18276-83-0 (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester 
• 99-73-0 para-bromophenacyl bromide 
• 136350-66-8 1-bromo-4-(2,2-dibromovinyl)benzene 
• 122-52-1 triethyl phosphite 

Downstream Products

• 18276-83-0 (2-oxo-(2-p-bromophenyl)ethyl)phosphonic acid diethyl ester 
• 1571900-39-4 2-ethoxy-4-(4-bromophenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide 

Relevant articles and documents

Rhodium(I)-Catalyzed Azide-Alkyne Cycloaddition (RhAAC) of Internal Alkynylphosphonates with High Regioselectivities under Mild Conditions

A regioselective method to access fully substituted 1,2,3-triazolyl-4-phosphonates from the internal alkynylphosphonates by rhodium(I)-catalyzed azide-alkyne cycloaddition (RhAAC) under mild conditions is reported. This approach is water and air compatible and has a broad substrate scope, good functional group tolerance, high yields and excellent regioselectivities. Fully substituted 1,2,3-triazolyl-4-phosphonates are directly prepared from the internal alkynylphosphonates by RhAAC with high 1,4-regioselectivities. The gram-scale preparation, application to carbohydrate synthesis and the solid-phase synthesis of triazolyl-4-phosphonates are highlights of this method. (Figure presented.).

Aerobic oxidative alkynylation of H-phosphonates and amides: An efficient route for the synthesis of alkynylphosphonates and ynamides using a recyclable Cu-MnO catalyst

An atom-economical and efficient route for the synthesis of alkynylphosphonates and ynamides by aerobic oxidative alkynylation of H-phosphonates and amides with both aliphatic and aromatic alkynes using our synthesized recyclable heterogeneous Cu-MnO catalyst has been developed. The phosphorylation was carried out under base- and ligand-free conditions, and in the presence of air as the sole oxidant. The reaction is compatible with a wide variety of functional groups and generates alkynylphosphonate and ynamide products in good to excellent yields. Both reactions can be scaled up to the gram scale without any decrease in the reaction yield and the reaction time is less compared to literature reports. The catalyst is recyclable and reused several times without any significant loss of reactivity.

Synthesis method of P-alkynyl phosphate compound

The invention relates to a synthesis method of a P-alkynyl phosphate compound. The synthesis method comprises the following steps: enabling a P-acylethyl phosphate compound, pyridinium salt and organic alkali to react with one another in an organic solven