134579-99-0

Basic information

• Product Name: 3,9-dimethyl[1,3]thiazolo[3,2-a][3,1]benzimidazol-9-ium iodide
• CAS NO: 134579-99-0
• Molecular Formula: C₁₁H₁₁IN₂S
• Molecular Weight: 330.1879
• Mol File: 134579-99-0.mol

Chemical Properties

• CAS DataBase Reference: 3,9-dimethyl[1,3]thiazolo[3,2-a][3,1]benzimidazol-9-ium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,9-dimethyl[1,3]thiazolo[3,2-a][3,1]benzimidazol-9-ium iodide(134579-99-0)
• EPA Substance Registry System: 3,9-dimethyl[1,3]thiazolo[3,2-a][3,1]benzimidazol-9-ium iodide(134579-99-0)

Safety Data

• Hazardous Substances Data: 134579-99-0(Hazardous Substances Data)

Upstream product

• 879283-39-3 3-(2-aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione 
• 5268-73-5 3-methylthiazolo[3,2-a]benzoimidazole 
• 74-88-4 methyl iodide 

Relevant articles and documents

Access to N-thioalkenyl and N-(o-thio)aryl-benzimidazol-2-ones by ring opening of thiazolobenzimidazolium and benzimidazobenzothiazolium salts and C-O bond cleavage of an alkoxide

We report herein the synthesis of highly functionalized 1,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo[2,1-b][1,3]benzothiazol-6-ium salts and an unusual C-O bond cleavage of an alkoxide. A large variety of benzimidazolones bearing an original N-thioalkenyl or N-(o-thio)aryl group was obtained in high yields. The developed chemistry provides efficient and rapid access to the privileged benzimidazol-2-one scaffold.

PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS

The invention relates to a new process leading to new substituted 1H-benzo[d]imidazol-2(3H)-ones of formula III and III′, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly as BACE 1 inhibitors in the treatment of Alzheimer disease.