13458-01-0

Basic information

• Product Name: 2-hydroxyethyl 4-methoxycarbonylphenyl sulfide
• Synonyms: 2-hydroxyethyl 4-methoxycarbonylphenyl sulfide
• CAS NO: 13458-01-0
• Molecular Weight: 212.269
• Mol File: 13458-01-0.mol

Chemical Properties

• CAS DataBase Reference: 2-hydroxyethyl 4-methoxycarbonylphenyl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyethyl 4-methoxycarbonylphenyl sulfide(13458-01-0)
• EPA Substance Registry System: 2-hydroxyethyl 4-methoxycarbonylphenyl sulfide(13458-01-0)

Safety Data

• Hazardous Substances Data: 13458-01-0(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 67-68-5 dimethyl sulfoxide 
• 60-24-2 2-hydroxyethanethiol 
• 125597-86-6 S-(2-hydroxyethyl) 4-toluenethiosulfonate 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 14184-32-8 4-(2-bromoethylsulfanyl)benzoic acid methyl ester 

Relevant articles and documents

Semiheterogeneous Dual Nickel/Photocatalytic (Thio)etherification Using Carbon Nitrides

A carbon nitride material can be combined with homogeneous nickel catalysts for light-mediated cross-couplings of aryl bromides with alcohols under mild conditions. The metal-free heterogeneous semiconductor is fully recyclable and couples a broad range of electron-poor aryl bromides with primary and secondary alcohols as well as water. The application for intramolecular reactions and the synthesis of active pharmaceutical ingredients was demonstrated. The catalytic protocol is applicable for the coupling of aryl iodides with thiols as well.

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates

An efficient deborylthiolation of aryl- and alkenylborons with thiosulfonates has been achieved under mild conditions using a copper catalyst. All steps of the experimental process were free from unpleasant odors. The mild reaction conditions as well as ready availability of boron compounds and thiosulfonates enabled easy access to an array of sulfides, including those bearing sensitive functional groups.

Nucleophilic aromatic substitution reaction of nitroarenes with alkyl- or arylthio groups in dimethyl sulfoxide by means of cesium carbonate

Treatment of nitroarenes having electron-withdrawing groups at the ortho or para position with alkanethiol in the presence of cesium carbonate in dimethyl sulfoxide at 25°C leads to nucleophilic displacement of the nitro group with the alkylthio group. Cesium carbonate is superior to other bases such as potassium carbonate, sodium carbonate, and triethylamine. The cesium-mediated nucleophilic aromatic substitution reaction provides a mild yet powerful and user-friendly protocol for the synthesis of aryl sulfides.