13458-54-3Relevant academic research and scientific papers
Synthesis of piperidine analogs of 1-(3- chlorophenyl)piperazine, a well known serotonin ligand
Radl, Stanislav,Hezky, Petr,Taimr, Jan,Proska, Jan,Krejci, Ivan
, p. 1017 - 1022 (1999)
Synthesis of arylpiperideines 3a-3d and arylpiperidines 4a- 4d as analogs of a well known serotonin ligand 1-(3- chlorophenyl)piperazine is reported. Starting aryllithium derivatives were treated with 1-methyl-piperdin-4-one to provide the corresponding hydroxy derivatives 6a and 6b. N- Methylpiperideine derivatives 3a and 3c were obtained by their dehydration while the corresponding N-unsubstituted compounds 3b and 3d were prepared indirectly by a three-step procedure. Hydrogenation of piperideine 3a provided the corresponding piperidine derivative 4a which after demethylation yielded 4b. Similar 4-pyridyl derivatives 4c and 4d were prepared by a similar strategy via the corresponding methoxy derivatives.
Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: A structure-activity study
Wimalasena, D. Shyamali,Perera, Rohan P.,Heyen, Bruce J.,Balasooriya, Inoka S.,Wimalasena, Kandatege
, p. 760 - 768 (2008/09/19)
The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition of mitochondrial complex
