1345823-38-2

Upstream product

• 103-80-0 phenylacetyl chloride 
• 88768-84-7 1-phenyl-4-trimethylsilylbutane-3-yn-2-one 
• 7438-05-3 1-azidooctane 
• 111-83-1 1-bromo-octane 
• 1345823-30-4 1-(1-(n-octyl)-1H-1,2,3-triazol-4-yl)-2-phenylethanone 
• 103-82-2 phenylacetic acid 

Relevant academic research and scientific papers

Synthesis and biological activities of triazole derivatives as inhibitors of InhA and antituberculosis agents

InhA, the enoyl reductase from the mycobacterial type II fatty acid biosynthesis pathway, is a target for the development of novel drugs against tuberculosis. We exploited copper-catalyzed [3+2] cycloaddition between alkynes and different azides to afford 1,4-disubstituted triazole or α-ketotriazole derivatives. Several compounds bearing a lipophilic chain mimicking the substrate were able to inhibit InhA. Among them, 1-dodecyl-4-phenethyl-1H-1,2,3-triazole displayed a minimum inhibitory concentration inferior to 2 μg/mL against Mycobacterium tuberculosis H37Rv.