1345823-41-7Relevant academic research and scientific papers
Synthesis and biological activities of triazole derivatives as inhibitors of InhA and antituberculosis agents
Menendez, Christophe,Gau, Sylvain,Lherbet, Christian,Rodriguez, Frédéric,Inard, Cyril,Pasca, Maria Rosalia,Baltas, Michel
, p. 5524 - 5531 (2011/12/15)
InhA, the enoyl reductase from the mycobacterial type II fatty acid biosynthesis pathway, is a target for the development of novel drugs against tuberculosis. We exploited copper-catalyzed [3+2] cycloaddition between alkynes and different azides to afford 1,4-disubstituted triazole or α-ketotriazole derivatives. Several compounds bearing a lipophilic chain mimicking the substrate were able to inhibit InhA. Among them, 1-dodecyl-4-phenethyl-1H-1,2,3-triazole displayed a minimum inhibitory concentration inferior to 2 μg/mL against Mycobacterium tuberculosis H37Rv.
