1345831-40-4Relevant academic research and scientific papers
Preparation of N-alkyl 2-pyridones via a lithium iodide promoted oto N-alkyl migration: Scope and mechanism
Tasker, Sarah Z.,Bosscher, Michael A.,Shandro, Christina A.,Ryu, Keun Ah,Snapper, Gregory S.,Utter, Jarrad M.,Anderson, Carolyn E.,Lanni, Erica L.,Ellsworth, Bruce A.
, p. 8220 - 8230,11 (2020/10/15)
An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.
Synthesis of a new class of β-iodo N-alkenyl 2-pyridones
Tasker, Sarah Z.,Brandsen, Benjamin M.,Ryu, Keun Ah,Snapper, Gregory S.,Staples, Richard J.,Dekock, Roger L.,Anderson, Carolyn E.
supporting information; experimental part, p. 6224 - 6227 (2012/01/19)
A new method for the synthesis of β-iodo N-alkenyl 2-pyridones from substituted 2-propargyloxypyridines has been discovered. These compounds present a unique complement of orthogonal functionality and structural characteristics that are unavailable via ot
