1345834-32-3Relevant academic research and scientific papers
Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure
Kawada, Yuji,Kodama, Tetsuya,Miyashita, Kazuyuki,Imanishi, Takeshi,Obika, Satoshi
, p. 5102 - 5108 (2012)
Previously, we reported that the 3,4-epoxypiperidine structure, whose design was based on the active site of DNA alkylating antitumor antibiotics, azinomycins A and B, possesses prominent DNA cleavage activity. In this report, novel caged DNA alkylating agents, which were designed to be activated by UV irradiation, were synthesized by the introduction of four photo-labile protecting groups to a 3,4-epoxypiperidine derivative. The DNA cleavage activity and cytotoxicity of the caged DNA alkylating agents were examined under UV irradiation. Four caged DNA alkylating agents showed various degrees of bioactivity depending on the photosensitivity of the protecting groups.
Light-controlled DNA binding of bisbenzamidines
Sanchez, Mateo I.,Vazquez, Olalla,Vazquez, M. Eugenio,Mascarenas, Jose L.
supporting information; experimental part, p. 11107 - 11109 (2011/11/12)
Caging of the amidinium moieties of two representative bisbenzamidine DNA binders with suitable photoresponsive protecting groups suppresses their DNA-binding, which can then be fully recovered upon irradiation with UV light that removes the caging groups
