1345841-47-5Relevant academic research and scientific papers
Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides
Liu, Yuanyuan,Zhang, Wanbin
, p. 2203 - 2206 (2013)
Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate. Copyright
Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41
Jiang, Shibo,Tala, Srinivasa R.,Lu, Hong,Zou, Peng,Avan, Ilker,Ibrahim, Tarek S.,Abo-Dya, Nader E.,Abdelmajeid, Abdelmotaal,Debnath, Asim K.,Katritzky, Alan R.
, p. 6895 - 6898 (2011/12/22)
Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a-h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki-Miyaura cross coupling, followed by a Knoevenagel condensation or Witt
