1345843-69-7

Basic information

• Product Name: 2-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)acetohydrazide
• CAS NO: 1345843-69-7
• Molecular Weight: 316.326
• Mol File: 1345843-69-7.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)acetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)acetohydrazide(1345843-69-7)
• EPA Substance Registry System: 2-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)acetohydrazide(1345843-69-7)

Safety Data

• Hazardous Substances Data: 1345843-69-7(Hazardous Substances Data)

Upstream product

• 107890-32-4 1-(4-trifluoromethylbenzyl)piperazine 
• 1345843-86-8 ethyl 2-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)acetate 

Downstream Products

• 1554476-45-7 N′-[(5-fluoro-2-hydroxy-3-propylphenyl)methylene]-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazineacetohydrazide 
• 1554476-23-1 N′-[[5-fluoro-2-hydroxy-3-(2-propenyl)phenyl]methylene]-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazineacetohydrazide 
• 1554476-03-7 N′-[(5-fluoro-2-hydroxyphenyl)methylene]-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazineacetohydrazide 
• 1554475-82-9 N′-[(2-hydroxy-3-propylphenyl)methylene]-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazineacetohydrazide 
• 1345850-97-6 N′-[[2-hydroxy-3-(2-propenyl)phenyl]methylene]-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazineacetohydrazide 

Relevant articles and documents

PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS

The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)

Procaspase-Activating Compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazone that enhances the enzymatic activity of procaspase-3 in vitro and induces apoptosis in cancer cells. An analogue of PAC-1, called S-PAC-1, was evaluated in a veterinary clinical trial in pet dogs with lymphoma and found to have considerable potential as an anticancer agent. With the goal of identifying more potent compounds in this promising class of experimental therapeutics, a combinatorial library based on PAC-1 was created, and the compounds were evaluated for their ability to induce death of cancer cells in culture. For library construction, 31 hydrazides were condensed in parallel with 27 aldehydes to create 837 PAC-1 analogues, with an average purity of 91%. The compounds were evaluated for their ability to induce apoptosis in cancer cells, and through this work, six compounds were discovered to be substantially more potent than PAC-1 and S-PAC-1. These six hits were further evaluated for their ability to relieve zinc-mediated inhibition of procaspase-3 in vitro. In general, the newly identified hit compounds are two- to four-fold more potent than PAC-1 and S-PAC-1 in cell culture, and thus have promise as experimental therapeutics for treatment of the many cancers that have elevated expression levels of procaspase-3.