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1345866-83-2

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1345866-83-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1345866-83-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,5,8,6 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1345866-83:
(9*1)+(8*3)+(7*4)+(6*5)+(5*8)+(4*6)+(3*6)+(2*8)+(1*3)=192
192 % 10 = 2
So 1345866-83-2 is a valid CAS Registry Number.

1345866-83-2Relevant articles and documents

PHOTORESPONSIVE NUTLIN DERIVATIVES AND USES THEREOF

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, (2020/05/15)

The invention relates to the field of medicine and medicinal chemistry, more in particular to the design, manufacture and use of anti-cancer drugs that can be activated by an external stimulus that can be applied in a spatiotemporal fashion. Provided herein is a compound having the chemical structure or a pharmaceutically acceptable salt thereof.

Spiroindolone polyethylene glycol carbonate compound, and compositions, preparation method and application thereof

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Paragraph 0081-0083, (2018/04/03)

The invention relates to a spiroindolone polyethylene glycol carbonate compound, compositions and a preparation method thereof, and an application of the spiroindolone polyethylene glycol carbonate compound as an anticancer drug due to antitumor activity of the spiroindolone polyethylene glycol carbonate compound. The spiroindolone polyethylene glycol carbonate compound has a structural formula asdescribed in the specification, has excellent tumor suppressive activity, good water solubility and low toxicity, and can be used for intravenous injections.

Synthesis of a spiroindolinone pyrrolidinecarboxamide MDM2 antagonist

Shu, Lianhe,Li, Zizhong,Gu, Chen,Fishlock, Dan

supporting information, p. 247 - 256 (2013/04/10)

A practical synthesis of a spiroindolinone pyrrolidinecarboxamide MDM2 antagonist 2 is reported. Cycloaddition of dipolarophile 3 with imine 30 afforded a complex mixture of diastereomers that were isomerized to the desired stereoisomer 31 by heating the mixture in the presence of DBU. After hydrolysis, the resulting product was resolved with a chiral amine to give an enantiopure acid which was converted to the target product 2. The process has been scaled up to a multihundred-gram scale. In addition, an asymmetric synthesis of 31 catalyzed by AgOAc and a chiral phosphine ligand was developed to give enantiomerically enriched 31, which was also converted to enantiopure 2.

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