1345869-76-2Relevant academic research and scientific papers
Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors
Gewald, Rainer,Rueger, Carla,Grunwald, Christian,Egerland, Ute,Hoefgen, Norbert
, p. 6652 - 6656 (2011/12/04)
The synthesis and SAR studies of a series of structurally novel inhibitors of PDE7 are discussed. The best compounds from the series display low nanomolar inhibitory activity and are selective versus other PDE isoenzymes.
