1345955-85-2

Upstream product

• 1260663-38-4 2,4,7-trichloropyrido[3,2-d]pyrimidine 
• 98-80-6 phenylboronic acid 
• 37538-68-4 pyrido<3,2-d>pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1345955-94-3 7-(2-furyl)-2-(3-methoxyphenyl)-4-phenyl-pyrido[3,2-d]pyrimidine 
• 1345955-95-4 2-(3-methoxyphenyl)-4-phenyl-7-(pyridin-3-yl)-pyrido[3,2-d]pyrimidine 
• 1345955-96-5 7-(3-benzothienyl)-2-(3-methoxyphenyl)-4-phenylpyrido[3,2-d]pyrimidine 
• 1345955-90-9 2-(3-methoxyphenyl)-7-(4-methoxyphenyl)-4-phenyl-pyrido[3,2-d]-pyrimidine 
• 1345955-91-0 7-(4-acetylphenyl)-2-(3-methoxyphenyl)-4-phenyl-pyrido[3,2-d]pyrimidine 
• 1345955-92-1 2-(3-methoxyphenyl)-7-(4-methylsulfonyl)-4-phenylpyrido[3,2-d]pyrimidine 
• 1345955-89-6 7-chloro-2-(2-methoxyphenyl)-4-phenyl-pyrido[3,2-d]pyrimidine 
• 1345955-88-5 7-chloro-2-(3-methoxyphenyl)-4-phenyl-pyrido[3,2-d]pyrimidine 
• 1345955-87-4 7-chloro-2-(4-methoxyphenyl)-4-phenyl-pyrido[3,2-d]pyrimidine 
• 1345955-93-2 2-(3-methoxyphenyl)-7-(3-naphthyl)-4-phenyl-pyrido[3,2-d]pyrimidine 

Relevant academic research and scientific papers

DERIVATIVES OF PYRIDO [3,2-D] PYRIMIDINE, METHODS FOR PREPARATION THEREOF AND THERAPEUTIC USES THEREOF

The present invention relates to a compound of the following general formula (I): wherein: R1 is notably H, a halogen or an aryl group,R2 is notably a halogen or an aryl group,R3 is notably a halogen, or an aryl or heteroaryl group, as well as to its pharmaceutically acceptable salts, its hydrates or its polymorphic crystalline structures, its racemates, diastereoisomers or enantiomers, except the compound 1-(2,4-diaminopyrido[3,2-d]pyrimidin-7-yl)-3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one.

Regiocontroled SNAr and palladium cross-coupling reactions of 2,4,7-trichloropyrido[3,2-d]pyrimidine

An efficient and original synthesis of various 2,4,7-trisubstituted pyrido[3,2-d]pyrimidines is reported. The first access to and the chemical interest of 2,4,7-trichloropyrido[3,2-d]pyrimidine is described. Double arylations and SNAr reactions occurred selectively at the C4 and C2 positions of 2,4,7-trichloropyrido[3,2-d]pyrimidine. The reactions at the C7 position were achieved under microwave irradiation in a few minutes. A one-step synthesis of a 2,4,7-tris(aminated) derivative was achieved as a highly efficient alternative. An efficient and original synthesis of 2,4,7-trisubstituted pyrido[3,2-d]pyrimidines is reported. Arylations and S NAr reactions occurred regioselectively at the C4 and C2 positions of 2,4,7-trichloropyrido[3,2-d]pyrimidine. Reactions at the C7 position were achieved under microwave irradiation in a few minutes. A one-step synthesis of a 2,4,7-tris(aminated) derivative was achieved as an efficient alternative. Copyright