1345968-41-3Relevant academic research and scientific papers
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors
Thompson, Lorin A.,Shi, Jianliang,Decicco, Carl P.,Tebben, Andrew J.,Olson, Richard E.,Boy, Kenneth M.,Guernon, Jason M.,Good, Andrew C.,Liauw, Ann,Zheng, Changsheng,Copeland, Robert A.,Combs, Andrew P.,Trainor, George L.,Camac, Daniel M.,Muckelbauer, Jodi K.,Lentz, Kimberley A.,Grace, James E.,Burton, Catherine R.,Toyn, Jeremy H.,Barten, Donna M.,Marcinkeviciene, Jovita,Meredith, Jere E.,Albright, Charles F.,MacOr, John E.
, p. 6909 - 6915 (2011/12/22)
The synthesis, evaluation, and structure-activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal and P-gp deficient mice is compared with data generated in normal rats.
