134599-57-8Relevant academic research and scientific papers
Ring Transformation of 4-Amino-1H-1,5-benzodiazepine-3-carbonitrile and Ethyl 4-Amino-1H-1,5-benzodiazepine-3-carboxylate into Benzimidazole Derivatives with Amines
Aotsuka, Tomoji,Okamoto, Yoshihisa,Takagi, Kaname,Hubert-Habart, Michel
, p. 485 - 487 (2007/10/02)
The ring contraction of 4-amino-1H-1,5-benzodiazepine-3-carbonitrile hydrochloride 1 and ethyl 4-amino-1H-1,5-benzodiazepine-3-carboxylate hydrochloride 2 with aromatic primary amines into benzimidazole derivatives 3 and 4 was readily accomplished by heating in methanol.Benzodiazepine 1 also reacted with methylamine and ethylamine at about 40 deg to give ring-opened amine adducts 7 which were recyclized to 1 with hydrochloric acid.
