1345992-70-2

Upstream product

• 19763-90-7 3,4-dichlorophenylhydrazine hydrochloride 
• 1345992-61-1 ethyl 5-amino-1-(3,4-dichlorophenyl)-4-ethyl-1H-pyrazole-3-carboxylate 
• 110-13-4 2,5-hexanedione 
• 1345992-59-7 potassium 3-cyano-1-ethoxy-1-oxopent-2-en-2-olate 

Downstream Products

• 1345992-57-5 N-(3,4-dichlorobenzyl)-1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-ethyl-1H-pyrazole-3-carboxamide 
• 1345992-58-6 N-cyclohexyl-1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-ethyl-1H-pyrazole-3-carboxamide 
• 1345992-80-4 1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-ethyl-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands

New 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as cannabinoid (CB) receptor ligands. Compound 11 (CB1 Ki = 2.3 nM, CB1 SI = 163.6) showed CB1 receptor affinity and selectivity superior to Rimonabant and AM251. Acute administration of 2 mg/kg 11 reduced sucrose, but not regular food, intake in rats. On the other hand, compound 23 (CB2 Ki = 0.51 nM, CB2 SI = 30.0) showed significant affinity and selectivity for the CB2 receptor. The results presented here show that the 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3- carboxamide may serve as an effective scaffold for the design of either CB 1 or CB2 receptor ligands.