134600-00-3

Basic information

• Product Name: 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
• Synonyms: 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 134600-00-3
• Molecular Weight: 255.233
• Mol File: 134600-00-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile(134600-00-3)
• EPA Substance Registry System: 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile(134600-00-3)

Safety Data

• Hazardous Substances Data: 134600-00-3(Hazardous Substances Data)

Upstream product

• 946-49-6 (E)-4-(4-nitrophenyl)-3-buten-2-one 
• 107-91-5 cyanoacetic acid amide 
• 4023-82-9 4-nitrobenzoylacetone 

Relevant articles and documents

Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase

Inspired by that the multi-target inhibitors against receptor tyrosine kinases (RTKs) have significantly improved the effect of clinical treatment for cancer, and based on the chemical structure of Linifanib (ABT-869, Abbott), two series of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure were designed and synthesized as multi-target inhibitors against RTKs. The preliminary biological evaluation showed that several compounds exhibited comparable potency with Linifanib. Compound S21 was identified as the most potent inhibitor against Fms-like tyrosine kinase 3 (FLT-3), kinase insert domain containing receptor (KDR) and platelet-derived growth factor receptor β (PDGFR-β) with its IC50 values were 4 nM, 3 nM and 8 nM respectively, it also showed potent inhibitory activities against several cancer cells.

SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME

The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts t

SYNTHESIS AND IDENTIFICATION OF ISOMERIC 4(6)-METHYL-6(4)-(SUBSTITUTED PHENYL)-3-CYANO-PYRIDONES

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