1346011-09-3

Basic information

• Product Name: C₂₁H₂₄N₂O₃
• CAS NO: 1346011-09-3
• Molecular Weight: 352.433
• Mol File: 1346011-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄N₂O₃(1346011-09-3)
• EPA Substance Registry System: C₂₁H₂₄N₂O₃(1346011-09-3)

Safety Data

• Hazardous Substances Data: 1346011-09-3(Hazardous Substances Data)

Upstream product

• 1210-83-9 N-acetyl-5-hydroxytryptamine 
• 588-63-6 3-phenoxypropyl bromide 
• 68062-88-4 N‐{2‐[5‐(benzyloxy)‐1H‐indol‐3‐yl]ethyl}acetamide 
• 2436-15-9 NSC 73391 

Relevant articles and documents

N-acetyl-5-arylalkoxytryptamine analogs: Probing the melatonin receptors for MT1-selectivity

A series of melatonin analogs obtained by the replacement of the ether methyl group with larger arylalkyl and aryloxyalkyl substituents was prepared in order to probe the melatonin receptors for MT1-selectivity. The most MT1-selective agents 11 and 15 were substituted with a Ph(CH 2)3 or a PhO(CH2)3 group. Compounds 11 and 15 displayed 11.5-fold and 11-fold higher affinity for the MT1 receptors than for the MT2 subtype. Interestingly, in our binding assay 11 and 15 have shown considerably higher MT1-affinity and selectivity than the reference ligand, the dimeric agomelatine 1a. The synthesis and pharmacological evaluation of a novel series of MLT analogs obtained by replacing the ether methyl group with arylalkyl and aryloxyalkyl moieties is described here. The results indicate for compounds 11 and 15 considerably higher MT1-affinity and selectivity than the reference ligand, the dimeric agomelatine 1a. Copyright