1346016-29-2Relevant academic research and scientific papers
Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines
Rossi, Daniela,Rui, Marta,Di Giacomo, Marcello,Schepmann, Dirk,Wünsch, Bernhard,Monteleone, Stefania,Liedl, Klaus R.,Collina, Simona
, p. 11 - 19 (2016/12/22)
Sigma Receptor (SR) modulators are involved in different signal transduction pathways, representing important pharmacological/therapeutic tools in several pathological conditions, such as neurodegenerative diseases and cancers. To this purpose, numerous c
Identification of a potent and selective ρ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells
Rossi, Daniela,Pedrali, Alice,Urbano, Mariangela,Gaggeri, Raffaella,Serra, Massimo,Fernández, Leyden,Fernández, Michael,Caballero, Julio,Ronsisvalle, Simone,Prezzavento, Orazio,Schepmann, Dirk,Wuensch, Bernhard,Peviani, Marco,Curti, Daniela,Azzolina, Ornella,Collina, Simona
experimental part, p. 6210 - 6224 (2011/12/02)
Herein we report the synthesis, drug-likeness evaluation, and in vitro studies of new sigma (ρ) ligands based on arylalkenylaminic scaffold. For the most active olefin the corresponding arylalkylamine was studied. Novel arylalkenylamines generally possess
