1346112-79-5

Basic information

• Product Name: 9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID
• Synonyms: (5Z)-7-[(2R,3S,4S)-Tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octenyl]-2H-pyran-3-yl]-5-heptenoic Acid-d4;(5Z,9α,13E,15S)9,11,15-TrihydroxythroMboxa-5,13-dien-1-oic Acid-d4;8-(1-Hydroxy-3-oxopropyl)-9,12-dihydroxy-5,10-heptadecadienoic Acid HeMiacetal-d4;TXB2-d4;THROMBOXANE B2-D4;9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID;XNRNNGPBEPRNAR-LCGOHBJFSA-N
• CAS NO: 1346112-79-5
• Molecular Formula: C20H30D4O6
• Molecular Weight: 374.51
• Product Categories: Pharmaceuticals;Fatty Acid Derivatives & Lipids;Glycerols;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities
• Mol File: 1346112-79-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID(1346112-79-5)
• EPA Substance Registry System: 9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID(1346112-79-5)

Safety Data

• Hazardous Substances Data: 1346112-79-5(Hazardous Substances Data)

Usage

Description

9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID, also known as Thromboxane A2 (TBXA2), is a biologically active eicosanoid derived from arachidonic acid. It plays a crucial role in platelet activation and aggregation, which are essential processes in wound healing and blood clotting. The compound is characterized by its complex chemical structure, with multiple hydroxy and double bond functionalities.

Uses

Used in Pharmaceutical Industry:
9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID is used as a labeled analogue of an inactive metabolite/product of Thromboxane A2 (TBXA2) for pharmaceutical research and development. It helps in understanding the role of TBXA2 in platelet activation and aggregation, which is vital for wound healing and blood clotting.
Used in Diagnostic Applications:
In the field of diagnostics, 9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID is used for urinary analysis of TXB2, which accurately reflects intrarenal TXA2 synthesis. Additionally, the measurement of 11-dehydro TBX2 (D230555) and 2,3-dinor thromboxane metabolites provides the best estimate of systemic TXA2 secretion, aiding in the assessment of various medical conditions related to blood clotting and platelet function.
Used in Research and Development:
9ALPHA,11,15S-TRIHYDROXY-THROMBA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID is also utilized in research and development for studying the mechanisms of platelet activation, aggregation, and blood clotting. This knowledge can be applied to develop new therapeutic strategies and treatments for conditions such as thrombosis, atherosclerosis, and other related disorders.