1346141-19-2

Upstream product

• 19094-56-5 2-chloro-5-iodobenzoic acid 
• 289039-54-9 ethyl 2-chloro-5-iodobenzoate 
• 1346141-18-1 ethyl 2-chloro-5-(cyclopropylethynyl)benzoate 
• 6746-94-7 Cyclopropylacetylene 
• 76008-73-6 5-Bromo-2-chloro-benzoic acid ethyl ester 

Downstream Products

• 1422205-83-1 2-chloro-5-(2-cyclopropylethyl)benzoic acid 

Relevant academic research and scientific papers

HETEROCYCLIC DERIVATIVE AS MICROSOMAL PROSTAGLANDIN E SYNTHASE (mPGEs) INHIBITOR

The present invention provides a novel heterocyclic derivative or a pharmaceutically acceptable salt thereof. For example, the present invention provides a heterocyclic derivative of the general formula [1] or its tautomer, or a pharmaceutically acceptable salt thereof: wherein R 1 and R 2 are same or diferent aromatic ring, etc., and ring A is a heterocyclic ring. The compound of the invention or a pharmaceutically acceptable salt thereof has potent mPGES-1 inhibiting activity and is useful as an agent for the treatment or prevension of a disease, such as rheumatoid arthritis, osteoarthritis, temporomandibular joint disorders, low back pain, endometriosis, dysmenorrhea, overactive bladder, malignant tumors or neurodegenerative disease.

New Pyrazolecarboxylic compd., its manufacturing method and pest control agents

PROBLEM TO BE SOLVED: To provide a new pyrazole compound capable of showing excellent biological activity to not only spider mites but also Nematoda. SOLUTION: It is found that a new pyrazole compound having a nitrogen-containing hetero ring in a first position of a pyrazole ring and a sulfonate group in a fifth position shows excellent biological activity to not only the spider mites but also the Nematoda. COPYRIGHT: (C)2012,JPOandINPIT