1346155-76-7Relevant academic research and scientific papers
Targeting the Warburg Effect in cancer; Relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
Brooke, Darby G.,Van Dam, Ellen M.,Watts, Colin K.W.,Khoury, Amanda,Dziadek, Marie A.,Brooks, Hilary,Graham, Lisa-Jane K.,Flanagan, Jack U.,Denny, William A.
, p. 1029 - 1039 (2014/02/14)
High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3) Such inhibitors are of interest due to PFKFB3's
Suzuki-aza-Wittig, Suzuki-condensation and aza-Wittig-electrocyclic ring-closure tandem reactions for synthesis of fused nitrogen-containing ring systems
Krajsovszky, Gabor,Karolyhazy, Laszlo,Dunkel, Petra,Boros, Sandor,Grillo, Antonino,Matyus, Peter
experimental part, p. 229 - 253 (2011/11/29)
We describe tandem combinations of Suzuki-aza-Wittig, Suzuki-condensation and aza-Wittig-electrocyclic ring closure reactions for the synthesis of new pyridazino[4,5-c]isoquinolinone, pyridazino[4,5-c]quinolinone and pyrimido[5,4-c]quinoline derivatives.
