1346162-68-2

Upstream product

• 34649-19-9 4,5-dibromo-1H-pyrrole-2-carbonitrile 
• 1346162-67-1 (2'S)-4,5-dibromo-1-(1'-hydroxy-4'-methoxybutan-2'-yl)-1H-pyrrole-2-carbonitrile 
• 98-59-9 p-toluenesulfonyl chloride 
• 1346162-66-0 (2'S)-4,5-dibromo-1-[1'-(tert-butyldiphenylsilyloxy)-4'-methoxybutan-2'-yl]-1H-pyrrole-2-carbonitrile 
• 1346162-56-8 (2'S)-4,5-dibromo-1-[1'-(tert-butyldiphenylsilyloxy)-4'-hydroxybutan-2'-yl]-1H-pyrrole-2-carbonitrile 

Relevant academic research and scientific papers

Organocatalytic enantioselective formal synthesis of bromopyrrole alkaloids via aza-Michael addition

An unprecedented organocatalytic enantioselective formal synthesis of bromopyrrole alkaloid natural products is reported. An organocatalytic aza-Michael addition using pyrroles as the N-centered nucleophile is utilized as the enantioselective step to construct the nitrogen-substituted stereogenic carbon center in bromopyrrole alkaloids in good yield and excellent enantioselectivity. The aza-Michael product is converted via lactamization using a Staudinger-type reductive cyclization to the key intermediate, which was previously used in the total synthesis of bromopyrrole alkaloid natural products.