1346165-10-3

Basic information

• Product Name: N,N-dimethyl-2-(2-methylphenylethynyl)aniline
• Synonyms: N,N-dimethyl-2-(2-methylphenylethynyl)aniline
• CAS NO: 1346165-10-3
• Molecular Weight: 235.329
• Mol File: 1346165-10-3.mol

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-2-(2-methylphenylethynyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-(2-methylphenylethynyl)aniline(1346165-10-3)
• EPA Substance Registry System: N,N-dimethyl-2-(2-methylphenylethynyl)aniline(1346165-10-3)

Safety Data

• Hazardous Substances Data: 1346165-10-3(Hazardous Substances Data)

Upstream product

• 766-47-2 1-ethynyl-2-methylbenzene 
• 698-02-2 N,N-dimethyl-o-iodoaniline 

Downstream Products

• 1448145-35-4 N-methyl-3-(phenylselenyl)-2-o-tolyl-1H-indole 
• 1097116-42-1 (1-methyl-1H-indol-3-yl)(o-tolyl)methanone 
• 1346164-96-2 1-methyl-3-(phenylthio)-2-o-tolyl-1H-indole 

Relevant articles and documents

CuBr-promoted tandem cyclization/trifluoromethylation of 2-alkynylanilines: Efficient synthesis of 3-trifluoromethylindoles

A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/ trifluoromethylation of 2-alkynylanilines and Umemoto’s reagent under effect of CuBr. The reaction features the use of cheap copper salt, mil

Au-promoted Pd-catalyzed arylative cyclization of N,N-dimethyl-o-alkynylaniline with aryl iodides: Access to 2,3-diaryl indoles and mechanistic insight

We have developed a Au-promoted Pd-catalyzed cyclization/cross-coupling of N,N-dimethyl-o-alkynylaniline with aryl iododes to synthesize 2,3-diarylindoles under mild and base-free conditions. A related vinyl-Au species has been isolated through Au-promoted cyclization of N,N-dimethyl-o-alkynylaniline and structurally characterized. Further study on its reactivity suggests the vinyl-Au species might be out of catalytic cycle, and PhPd(OTf)(PPh3)2 is probably the reaction intermediate.