1346170-49-7Relevant academic research and scientific papers
An efficient synthesis of cyclopropyl silyl ketones
Honda, Mitsunori,Nakae, Kenta,Nishizawa, Toshiaki,Suda, Mitsuhiro,Kunimoto, Ko-Ki,Segi, Masahito
, p. 9500 - 9508 (2012/01/02)
The reaction of silylcyclopropyl bromides with dichloromethyl methyl ether in the presence of n-butyllithium is investigated. Under basic reaction conditions, the corresponding cyclopropylidene derivatives are exclusively obtained. The resulting cyclopropylidene compounds are subjected to protonolysis or trapping with electrophiles in a one-pot to give the cyclopropyl silyl ketone derivatives in good yields. Acidic treatment of derived cyclopropyl silyl ketone allows isomerization to give the thermodynamically favorable trans form exclusively.
