134618-72-7Relevant articles and documents
6-Demethyl-6-halo- and 6-Demethyl-6-thiomitomycins: Synthesis of Novel Mitomycin Derivatives Involving a Tandem Michael Addition/Retro-Mannich Reaction Sequence
Arai, Hitoshi,Kasai, Masaji
, p. 1087 - 1094 (2007/10/02)
Synthesis of novel 6-demethyl-6-halomitomycins (3, 4, 6, and 7) and 6-demethyl-6-thiomytomycins (5 and 8) is described from key intermediates, namely, 6-demethyl-7,7-(ethylenedioxy)-6,6-dihalo-6,7-dihydromitosanes (18 and 19) and 6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-thiomitosane (20), respectively.Compounds 18-20 were prepared through a tandem Michael addition and a retro-Mannich reaction sequence (N-halosucinimide or cationic arylsulfenyl species in the presence of Et2NH) on 10.
An unusual replacement of a methylene moiety by a phenylseleno group. Synthesis of mitomycin C labelled at c-6 by 13CH3 and C2H3
Kasai,Arai,Kanda
, p. 600 - 601 (2007/10/02)
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