134618-72-7

Upstream product

• 122644-74-0 1a-acetyl-7-demethoxy-6,7-dihydro-7,7-(ethylenedioxy)-6-(phenylselenyl)mitomycin A 
• 122644-75-1 6-Demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-methylidenemitosane 
• 82737-08-4 N-(phenylselanyl)morpholine 

Downstream Products

• 134618-75-0 -1a-Acetyl-7-demethoxy-7,7-(ethylenedioxy)-6,7-dihydro-6-(phenylseleno)mitomycin A 
• 145650-89-1 6-demethyl-6-ethylmitomycin C 
• 134645-95-7 -1a-Acetyl-7-demethoxy-7,7-(ethylenedioxy)-6,7-dihydro-6-(phenylseleno)mitomycin A 

Relevant academic research and scientific papers

6-Demethyl-6-halo- and 6-Demethyl-6-thiomitomycins: Synthesis of Novel Mitomycin Derivatives Involving a Tandem Michael Addition/Retro-Mannich Reaction Sequence

Synthesis of novel 6-demethyl-6-halomitomycins (3, 4, 6, and 7) and 6-demethyl-6-thiomytomycins (5 and 8) is described from key intermediates, namely, 6-demethyl-7,7-(ethylenedioxy)-6,6-dihalo-6,7-dihydromitosanes (18 and 19) and 6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-thiomitosane (20), respectively.Compounds 18-20 were prepared through a tandem Michael addition and a retro-Mannich reaction sequence (N-halosucinimide or cationic arylsulfenyl species in the presence of Et2NH) on 10.