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Epitope mapping immunodominant regions of the pilA protein (cas 134632-31-8) of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates08/06/2019

We designed and tested three PilA-derived vaccine candidates in a chinchilla model of ascending nontypeable Haemophilus influenzae (NTHI)-induced otitis media (OM). Delivery of antiserum directed against each immunogen conferred varying degrees of protection. Presentation of a B-cell epitope der...detailed

Isolation and Biochemical Characterization of the pilA protein (cas 134632-31-8) ofNeisseria meningitidis08/05/2019

PilA is the response regulator of a two-component regulatory system that controls a number of genes in the pathogenic Neisseria. Previous work has shown thatNeisseria gonorrhoeae(GC) PilA binds DNA and also hydrolyzes GTP. Here, we report the cloning, sequencing, purification, and biochemical ch...detailed

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