1346414-21-8

Basic information

• Product Name: 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
• Synonyms: 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
• CAS NO: 1346414-21-8
• Molecular Formula: C₁₆H₁₃ClN₂S
• Molecular Weight: 300.81
• Mol File: 1346414-21-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 231-232 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
• Boiling Point: 539.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 1.84±0.20(Predicted)
• CAS DataBase Reference: 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE(1346414-21-8)
• EPA Substance Registry System: 2-([(E)-(4-CHLOROPHENYL)METHYLIDENE]AMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE(1346414-21-8)

Safety Data

• Hazardous Substances Data: 1346414-21-8(Hazardous Substances Data)

Upstream product

• 4651-91-6 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Synthesis of novel schiff bases by microwave irradiation and their in vitro antibacterial activity

A series of thiophene-3-carbonitrile contaning schiff bases were synthesized, characterized by the reaction of 2-amino-4,5,6,7-tetrahydrobenzo[ b]thiophene-3-carbonitrile and corresponding active aldehyde under microwave irradiation and screened for their antibacterial activities. The structure of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analyses. The antibacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration was determined with the reference of standard drug chloramphenicol. The results showed that compound 6 is better at inhibiting the growth as compared to chloramphenicol against both types of the bacteria (gram-positive and gram-negative).