1346444-74-3

Upstream product

• 103-04-8 (phenylthio)acetic acid 
• 870-46-2 t-butoxycarbonylhydrazine 
• 1346444-72-1 N'-(2-phenylsulfanylacetyl)hydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 1346444-76-5 N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester 
• 1346444-95-8 C₅₂H₇₀N₁₀O₁₆S 
• 1346444-92-5 [(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester 
• 1332707-91-1 3-benzenesulfonyl-5,7-dimethylchromen-2-one 
• 1346444-82-3 C₂₉H₃₄N₂O₆S₂ 
• 1346444-80-1 C₃₆H₃₉N₃O₈S₂ 

Relevant academic research and scientific papers

Development of UV-responsive catch-and-release system of a cysteine protease model peptide

Cysteine proteases are attractive drug targets due to their involvement in a wide variety of diseases. To evaluate the potential of a particular protease as a drug target, use of a reagent that controls activity of the protease is indispensable. In this context, we have developed a catch-and-release reagent that first forms a covalent bond with the active center thiol of a cysteine protease to suppress its activity and then is removed by UV-irradiation to release the parent active protease. In this paper, the design and synthesis of a catch-and-release reagent of thiols are described. Its application to caging (catch) and UV-induced uncaging (release) of a model peptide derived from an active site of caspase-9 and introduction of a recognition moiety on the reagent are also reported.