Clofarabine triphosphate is a bioactive metabolite of Clofarabine (C586890), a nucleoside analogue and an antineoplastic agent. It plays a crucial role in the therapeutic effects of Clofarabine by inhibiting DNA synthesis and function, thereby exerting its anticancer properties.
134646-41-6
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Basic information
- Product Name: Clofarabine Triphosphate
- Synonyms: Clofarabine Triphosphate
- CAS NO:134646-41-6
- Molecular Formula: C10H14ClFN5O12P3
- Molecular Weight: 543.6171462
- EINECS: N/A
- Product Categories: Bases & Related Reagents;Inhibitors;Intermediates & Fine Chemicals;Metabolites & Impurities;Nucleotides;Pharmaceuticals;Metabolites & Impurities, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 134646-41-6.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Clofarabine Triphosphate(CAS DataBase Reference)
- NIST Chemistry Reference: Clofarabine Triphosphate(134646-41-6)
- EPA Substance Registry System: Clofarabine Triphosphate(134646-41-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 134646-41-6(Hazardous Substances Data)
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134646-41-6 Usage
Uses
Used in Oncology:Clofarabine triphosphate is used as an anticancer agent for the treatment of various malignancies, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It is particularly effective in cases of relapsed or refractory leukemia, where conventional chemotherapy has failed.
Clofarabine triphosphate is used as a therapeutic agent for its ability to inhibit DNA synthesis and function, leading to the disruption of cancer cell replication and induction of apoptosis.
Used in Drug Development:
Clofarabine triphosphate is also used in the research and development of new antineoplastic agents, as it serves as a reference compound for the design and synthesis of novel nucleoside analogues with improved efficacy and reduced toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 134646-41-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,6,4 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.Calculate Digit Verification of CAS Registry Number 134646-41:
(8*1)+(7*3)+(6*4)+(5*6)+(4*4)+(3*6)+(2*4)+(1*1)=126
126 % 10 = 6
So 134646-41-6 is a valid CAS Registry Number.
134646-41-6Upstream product
134646-41-6Downstream Products
134646-41-6Related news
A sensitive LC–MS/MS method for quantifying Clofarabine Triphosphate (cas 134646-41-6) concentrations in human peripheral blood mononuclear cells07/31/2019
Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for quantifying clofarabine triphosphate concentrations in human pe...detailed
Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and Clofarabine Triphosphate (cas 134646-41-6) by LC–MS/MS in human cancer cells07/30/2019
Purine nucleoside analogues are widely used in the treatment of haematological malignancies, and their biological activity is dependent on the intracellular accumulation of their triphosphorylated metabolites. In this context, we developed and validated a liquid chromatography tandem mass spectr...detailed
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Clofarabine Triphosphate
