1346513-46-9

Basic information

• Product Name: C₂₂H₂₁ClO₂
• Synonyms: C₂₂H₂₁ClO₂
• CAS NO: 1346513-46-9
• Molecular Weight: 352.861
• Mol File: 1346513-46-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁ClO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁ClO₂(1346513-46-9)
• EPA Substance Registry System: C₂₂H₂₁ClO₂(1346513-46-9)

Safety Data

• Hazardous Substances Data: 1346513-46-9(Hazardous Substances Data)

Upstream product

• 1202-60-4 3-(4-chlorophenyl)-3-methyl-2-acrylic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 1012-17-5 3-(4-chlorophenyl)-2-methylpropanoic acid 

Relevant articles and documents

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.