1346528-90-2Relevant academic research and scientific papers
Enantioselective preparation of P-chiral phosphine oxides
Adams, Harry,Collins, Rebecca C.,Jones, Simon,Warner, Christopher J. A.
, p. 6576 - 6579 (2012/01/15)
A highly efficient chiral auxiliary-based strategy for the asymmetric synthesis of P-chiral phosphine oxides in >98:2 er has been developed. The methodology involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides.
