1346547-00-9

Basic information

• Product Name: GSK583
• Synonyms: GSK583;SK583
• CAS NO: 1346547-00-9
• Molecular Formula: C20H19FN4O2S
• Molecular Weight: 398.4538632
• EINECS: -0
• Mol File: 1346547-00-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 652.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.402±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Soluble in DMSO (up to at least 25 mg/ml).
• PKA: 12.59±0.40(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• CAS DataBase Reference: GSK583(CAS DataBase Reference)
• NIST Chemistry Reference: GSK583(1346547-00-9)
• EPA Substance Registry System: GSK583(1346547-00-9)

Safety Data

• Hazardous Substances Data: 1346547-00-9(Hazardous Substances Data)

Usage

Description

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50?= 5 nM human and IC50?= 2 nM rat.1?It also potently inhibits isolated RIP3 kinase (IC50?= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

Uses

GSK 583, is a selective inhibitor of RIP-like interacting CLARP kinase RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.

References

1) Haile?et al.?(2016),?The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine; J. Med. Chem.,?59?4867 2) Goncharov?et al.?(2018),?Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling; Mol. Cell,?69?551