13466-35-8

Basic information

• Product Name: 3-Chloropyridin-2-ol
• Synonyms: 2-HYDROXY-3-CHLOROPYRIDINE;3-CHLORO-2-HYDROXYPYRIDINE;3-CHLORO-2-PYRIDINOL;3-CHLOROPYRIDIN-2-OL;3-Chloro-2(1H)-pyridone;2(1H)-Pyridinone,3-chloro-(9CI);3-Chloro-1H-pyridin-2-one;3-Chloro-2-pyridinol,3-Chloro-2-pyridinol
• CAS NO: 13466-35-8
• Molecular Formula: C₅H₄ClNO
• Molecular Weight: 129.54
• EINECS: -0
• Product Categories: PYRIDINE;pharmacetical;Pyridines
• Mol File: 13466-35-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 180-182°C
• Boiling Point: 319.5 °C at 760 mmHg
• Flash Point: 147 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0.000338mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Room temperature.
• PKA: 10.53±0.10(Predicted)
• Water Solubility: Soluble in water (25 deg C)
• BRN: 109845
• CAS DataBase Reference: 3-Chloropyridin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloropyridin-2-ol(13466-35-8)
• EPA Substance Registry System: 3-Chloropyridin-2-ol(13466-35-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 22-26-36/37-39-37
• Hazardous Substances Data: 13466-35-8(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Uses

3-Chloro-2-hydroxypyridine is used as an organic intermediate.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 6695, 1996 DOI: 10.1016/S0040-4039(96)01449-9

InChI:InChI=1/C5H4ClNO/c6-4-2-1-3-7-5(4)8/h1-3H,(H,7,8)

Upstream product

• 1163681-53-5 3-chloro-2-iodo-1-methylpyridinium iodide 
• 104-94-9 4-methoxy-aniline 
• 100-01-6 4-nitro-aniline 
• 62-53-3 aniline 
• 675-20-7 piperidin-2-one 
• 2402-77-9 2,3-dichloro-pyridine 
• 6515-09-9 2,3,6-trichloropyridine 
• 13466-43-8 3-bromo-pyridin-2-ol 
• 98273-80-4 2-acetyloxy-3-chloropyridine 

Downstream Products

• 79674-54-7 C₁₀H₁₂ClNO₃ 
• 1446704-76-2 C₁₀H₁₂ClNO₃ 
• 109822-14-2 3-chloro-2H-[1,2'-bipyridin]-2-one 
• 2402-77-9 2,3-dichloro-pyridine 

Relevant articles and documents

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Preparation method of 2,3-dichloropyridine

The invention provides a preparation method of 2,3-dichloropyridine. The method comprises the following steps: preparing 2,3-dichloropyridine through an intermediate product 2-hydroxy-3-chloropyridine; preparing 3,3-dichloro-2-piperidone through a chlorination reaction by using 2-piperidone as a raw material; then preparing 2-hydroxy-3-chloropyridine through an elimination and oxidation reaction;and finally preparing the 2,3-dichloropyridine through a substitution reaction under action of the obtained 2-hydroxy-3-chloropyridine and a chlorination reagent. The method has the advantages of cheap and easily obtained raw materials, low cost, stable reaction intermediate and raw materials, safe and simple operation, less waste water generation, environmental protection, high reaction selectivity, few side reactions, and high product yield and purity, and is suitability for industrial production.

Preparation method of 2,3-dichloropyridine

The invention provides a preparation method of 2,3-dichloropyridine. The 2,3-dichloropyridine is prepared by a one-pot method, pyridine alkyl ester serves as a raw material, and synthesis is conductedby a mode of performing chlorination, performing hydrolysis and performing chlorination again; the chlorination is substitution reaction, substitution on a benzene ring is relatively easy, the alkylester group can protect the site of the first-time chlorination reaction to be at 2 position, the hydrolysis reaction is mild in condition and rapid in reaction compared with the prior art, the second-time chlorination is to substitute the hydroxyl, the reaction is easy and the reaction condition is relatively mild. The preparation method provided by the invention is simple in operation, few threewastes are generated in the production process, requirements on equipment are low and the yield is high.