134660-06-3

Basic information

• Product Name: methyl 2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythropentofuranoside
• Synonyms: methyl 2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythropentofuranoside
• CAS NO: 134660-06-3
• Molecular Weight: 329.191
• Mol File: 134660-06-3.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythropentofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythropentofuranoside(134660-06-3)
• EPA Substance Registry System: methyl 2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythropentofuranoside(134660-06-3)

Safety Data

• Hazardous Substances Data: 134660-06-3(Hazardous Substances Data)

Upstream product

• 133635-44-6 methyl 2,3-dideoxy-5-O-(4-methylbenzoyl)-D-glycero-pentofuranoside 

Downstream Products

• 84414-90-4 1-(2,3-dideoxy-α-D-glycero-pent-2-enofuranosyl)thymine 
• 114672-74-1 1-(3-deoxy-β-D-threo-pentofuranosyl)thymine 
• 134660-09-6 4-Methyl-benzoic acid (2S,4R)-4-bromo-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 134660-10-9 4-Methyl-benzoic acid (2S,4R)-4-bromo-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 134660-08-5 1-<2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythro-pentofuranosyl>uracil 
• 134660-07-4 methyl 2,3-dideoxy-5-O-(4-methylbenzoyl)-D-glycero-pent-2-enofuranoside 

Relevant articles and documents

Synthesis of 2'-azido, 2,2'-anhydro and 2',5'-anhydro nucleosides with potential anti-HIV activity

Reaction of methyl 2-bromo-2,3-dideoxy-5-O-(4-methylbenzoyl)-D-erythro-pentofuranoside (7) with silylated uracils 9 using trimethylsilyl triflate as catalyst afforded the corresponding 2'-bromonucleosides 10. 2,3-Didehydro sugar 8 was prepared by heating 7 with sodium azide in dimethylformamide. 2,2'-Anhydronucleosides 1 were prepared by treating the nucleosides 10 with sodium methoxide at room temperature. 1-(2-Azido-2,3-dideoxy-β-D-threo-pentofuranosyl)thymine (15) and its α-anomer (16) were prepared by treating 10c with sodium azide and subsequently methanolic ammonia. Treatment of 1-(2-bromo-2,3-dideoxy-α-D-erythro-pentofuranosyl)thymine (11c) with excess of sodium methoxide under reflux gave the corresponding 2',5'-anhydro nucleoside 17.