1346600-58-5

Basic information

• Product Name: Nordihydro Guaiaretic Acid-d6
• Synonyms: Nordihydro Guaiaretic Acid-d6;4,4'-(2,3-DiMethyl-1,4-butanediyl)bis-1,2-benzene-d3-diol;4,4'-(2,3-DiMethyltetraMethylene)dipyrocatechol-d6;Dihydronorguaiaretic Acid-d6;NDGA-d6;NSC 4291-d6;β,γ-DiMethyl-α,δ-bis(3,4-dihydroxyphenyl-d3)butane
• CAS NO: 1346600-58-5
• Molecular Formula: C18H22O4
• Molecular Weight: 302.36488
• Product Categories: Aromatics;Inhibitors;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
• Mol File: 1346600-58-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Nordihydro Guaiaretic Acid-d6(CAS DataBase Reference)
• NIST Chemistry Reference: Nordihydro Guaiaretic Acid-d6(1346600-58-5)
• EPA Substance Registry System: Nordihydro Guaiaretic Acid-d6(1346600-58-5)

Safety Data

• Hazardous Substances Data: 1346600-58-5(Hazardous Substances Data)

Usage

Description

Nordihydro Guaiaretic Acid-d6 is a deuterated compound derived from Nordihydro Guaiaretic Acid, which is a naturally occurring compound found in the creosote bush and the guaiac wood. It is a labeled lipoxygenase inhibitor with a polyphenol-bearing o-dihydroxy (catechol) structure. Nordihydro Guaiaretic Acid-d6 is characterized by its high inhibitory activity and is used in various applications due to its unique properties.

Uses

Used in Pharmaceutical Industry:
Nordihydro Guaiaretic Acid-d6 is used as a labeled lipoxygenase inhibitor for its high inhibitory activity against broad bean lipoxygenase. It is particularly effective as an oxidation product from Resveratrol (R150000), where it demonstrates significantly higher inhibitory activity compared to Resveratrol itself, which has low oxidation efficiency.
Used in Research and Development:
In the field of research and development, Nordihydro Guaiaretic Acid-d6 serves as a valuable tool for studying the mechanisms of lipoxygenase inhibition and the role of polyphenol-bearing o-dihydroxy (catechol) structures in biological systems. Its deuterated nature allows for easier detection and tracking in various experimental setups, making it a useful compound for scientific investigations.
Used in Drug Discovery:
Nordihydro Guaiaretic Acid-d6 can be employed in drug discovery processes to identify potential therapeutic agents that target lipoxygenase enzymes. Its high inhibitory activity and unique structural features make it a promising starting point for the development of new drugs aimed at treating conditions related to lipoxygenase overactivity or dysfunction.