134664-69-0

Basic information

• Product Name: 2-Hexanone, 5-methyl-1-(triphenylphosphoranylidene)-
• CAS NO: 134664-69-0
• Molecular Formula: C25H27OP
• Molecular Weight: 374.463
• Mol File: 134664-69-0.mol

Chemical Properties

• CAS DataBase Reference: 2-Hexanone, 5-methyl-1-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexanone, 5-methyl-1-(triphenylphosphoranylidene)-(134664-69-0)
• EPA Substance Registry System: 2-Hexanone, 5-methyl-1-(triphenylphosphoranylidene)-(134664-69-0)

Safety Data

• Hazardous Substances Data: 134664-69-0(Hazardous Substances Data)

Upstream product

• 110-12-3 5-Methyl-2-hexanone 
• 603-35-0 triphenylphosphine 
• 136604-90-5 1-bromo-5-methylhexan-2-one 
• 513-38-2 Isobutyl iodide 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 

Downstream Products

• 82297-69-6 1-(4-methoxyphenyl)-6-methylhept-1-en-3-one 
• 850807-35-1 3-(tert-butyldimethylsilyloxy)-1-(4-methoxyphenyl)-6-methyl-(1E,3Z)-heptadiene 
• 134664-58-7 (5Z,7E,22E)-(1S,3R,24S)-24-isoamyl-9,10-secochola-5,7,10⁽¹⁹⁾,22-tetraene-1,3,24-triol 
• 133737-32-3 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone 

Relevant articles and documents

Tandem Wittig Reaction-Ring Contraction of Cyclobutanes: A Route to Functionalized Cyclopropanecarbaldehydes

An original tandem reaction consisting of a Wittig reaction-ring contraction process between α-hydroxycyclobutanone and phosphonium ylides has been developed. Highly functionalized cyclopropanecarbaldehydes are obtained in good to high yield.

Highly substituted tetrahydropyrones from hetero-Diels-Alder reactions of 2-alkenals with stereochemical induction from chiral dienes

(Chemical Equation Presented) A new method for the stereoselective synthesis of libraries of 2,3,5-trisubstituted tetrahydro-γ-pyrones and the corresponding tetrahydropyran-4-ols is reported. Dienes with a chiral moiety at position 5 were synthesized star

An Efficient and Cost-Effective Synthesis of Pagoclone

The compound (+)-2-(7-chloro-1,8-naphthyridin-2-yl)-3S-(5-methyl-2- oxohexyl)-l-isoindolinone (pagoclone) shows anxiolytic activity due to partial agonism of the benzodiazepine site of the GABAA receptor. We describe the development of an economical and practical process for a 100+ kg pilot plant production used to supply development needs. For the key reaction, a β-keto phosphonium salt was prepared by selectively reacting a primary α-bromo ketone with triphenylphosphine in the presence of a secondary α-bromo ketone. A novel Wittig reaction with a 1-isoindolinone was used to produce racemic pagoclone. The enantiomerically pure drug substance was prepared by hydrolyzing a γ-lactam and resolving the resulting enantiomeric carboxylic acids with (+)-ephedrine hemihydrate. An alternate resolution, involving chiral multicolumn chromatography (MCC) was also developed. The synthesis was completed by a racemization-free lactam formation to afford pagoclone.

24-homo vitamin D derivatives, process for their production and pharmaceutical preparations obtained therefrom

New 24-homo vitamin D derivatives of formula I STR1 are described, in which R1 means a hydrogen atom, a hydroxy, an alkanoyloxy group with 1 to 8 carbon atoms or an aralkanoyloxy group with up to 8 carbon atoms, R2 and R3,