1346667-99-9Relevant academic research and scientific papers
tert-BuOK-mediated carbanion-yne intramolecular cyclization: Synthesis of 2-substituted 3-benzylbenzofurans
Chen, Po-Yuan,Wang, Tzu-Pin,Huang, Keng-Shiang,Kao, Chai-Lin,Tsai, Jui-Chi,Wang, Eng-Chi
, p. 9291 - 9297 (2011/12/02)
A mild, efficient, and regioselective carbanion-yne intramolecular cyclization mediated by t-BuOK for the synthesis of 2-substituted 3-benzylbenzofurans is developed. It was started from o-iodophenol (1), based on O-alkylation, and the Sonogashira reaction in sequence to produce 2-(2-phenylethynylphenoxy)-1-arylalkanones (5). An intramolecular carbanion-yne 5-exo-dig cyclization reaction of 5, which was mediated by t-BuOK, yielded title benzofurans in good yields.
