1346682-65-2Relevant academic research and scientific papers
Triflic acid catalysed regioselective synthesis of substituted naphthalenes by benzannulation of carbonyls with alkynes
Gudla, Vanajakshi,Sudheer, Mokhamatam,Rao, Chinthu Joginarayana,Sanasi, Paul Douglas,Battula, Venkateswara Rao
, (2021/05/31)
An interesting and facile triflic acid catalysed annulation of α-aryl carbonyls with arylalkynes is presented for the regioselective synthesis of substituted naphthalenes. The annulation reaction involves a sequence of electrophilic attack of carbonyl on arylalkyne and benzannulation catalysed by triflic acid. The present catalyst effects this transformation at room temperature itself. Intramolecular version of the present Br?nsted acid catalysis furnished compounds containing 1-arylnaphthalene core fused with ring systems in excellent yields.
Synthesis of arylnaphthalene lignan scaffold by gold-catalyzed intramolecular sequential electrophilic addition and benzannulation
Gudla, Vanajakshi,Balamurugan, Rengarajan
experimental part, p. 9919 - 9933 (2012/01/15)
An intramolecular approach to generate compounds containing an arylnaphthalene lignan scaffold in high yields is presented. It involves a sequential intramolecular electrophilic attack of carbonyl on arylalkyne followed by benzannulation catalyzed by gold salt. AuCl3 in combination with AgSbF6 works better to effect this transformation. Selected products have been converted into arylnaphthalene lactone natural products such as justicidin E, taiwanin C, and retrojusticidin B (Figure presented).
