1346683-42-8

Basic information

• Product Name: 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]aMino]-
• Synonyms: 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]aMino]-;3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2- (1-pyrrolidinyl)cyclohexyl]amino]-3-cyclobutene-1,2- dione;3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2- (1-pyrrolidinyl)cyclohexyl]amino]-3-cyclobutene-1,2- dione,99%e.e.;3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)
• CAS NO: 1346683-42-8
• Molecular Formula: C22H23F6N3O2
• Molecular Weight: 475.4273392
• Mol File: 1346683-42-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 465.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 9.73±0.20(Predicted)
• CAS DataBase Reference: 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]aMino]-(1346683-42-8)
• EPA Substance Registry System: 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]aMino]-(1346683-42-8)

Safety Data

• Hazardous Substances Data: 1346683-42-8(Hazardous Substances Data)

Usage

General Description

3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]aMino]- is a chemical compound with a complex molecular structure. It contains amines and cyclohexyl groups, as well as trifluoromethyl and pyrrolidinyl moieties. The compound may have potential pharmaceutical or industrial applications due to its unique structure and functional groups. Further research and analysis are required to fully understand and utilize the properties and potential uses of this chemical.

Upstream product

• 1223105-85-8 3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione 
• 1261082-38-5 allyl ((1R,2S)-2-aminocyclohexyl)carbamate 
• 885677-92-9 (1R,2R)-2-(pyrrolidin-1-yl)cyclohexan-1-amine 
• 1233032-09-1 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Relevant articles and documents

Highly enantioselective one-pot sequential synthesis of valerolactones and pyrazolones bearing all-carbon quaternary stereocentres

Highly enantiopure and bioactive δ-valerolactones and pyrazolones, bearing α-all-carbon quaternary stereocentres, were successfully and sequentially preparedviaa one-pot procedure starting from readily available, inexpensive materials, catalysed by a new chiral squaramide under mild reaction conditions. An organocatalytic Michael reaction afforded the valerolactones, while a one-pot Michael-hydrazinolysis-imidization cascade yielded the pyrazolones. This procedure is economically efficient and environmentally benign.

Squaramide-catalyzed enantioselective Michael addition of masked acyl cyanides to substituted enones

Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective Michael addition to substituted enones. The reactions are catalyzed by chiral squaramides and afford adducts in high yields (90-99%) and with excellent enantioselectivities (85-98%). The addition products are unmasked to produce dicyanohydrins that, upon treatment with a variety of nucleophiles, provide γ-keto acids, esters, and amides. The use of this umpolung synthon has enabled, in enantiomerically enriched form, the first total synthesis of the prenylated phenol (+)-fornicin C.