1346697-16-2Relevant academic research and scientific papers
Nature of the intermediates in gold(I)-catalyzed cyclizations of 1,5-enynes
Lopez-Carrillo, Veronica,Huguet, Nuria,Mosquera, Ungeles,Echavarren, Antonio M.
, p. 10972 - 10978 (2011/10/18)
The carbene or carbocationic nature of the intermediates in the gold-catalyzed cycloisomerization of 1,5-enynes can be revealed, depending on the ligands on the gold catalysts. Gold complexes with highly electron-donating ligands promote reactions that proceed via intermediates with carbene-like character, leading to products with a bicyclo[3.1.0]hexene skeleton. The intermediate cyclopropyl endo-gold carbenes formed in this cyclization have been trapped, for the first time, to give biscyclopropane derivatives in a reaction that proceeds in a concerted fashion, according to DFT calculations.
