134672-70-1

Basic information

• Product Name: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID
• Synonyms: 3-(2',4'-DIFLUOROPHENYL)PROPIONIC ACID;3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID;2,4-Difluorobenzenepropanoic acid;Benzenepropanoic acid, 2,4-difluoro-;3-(2,4-Difluorophenyl)propionic acid 97%
• CAS NO: 134672-70-1
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.16
• Product Categories: C9;Carbonyl Compounds;Carboxylic Acids
• Mol File: 134672-70-1.mol

Chemical Properties

• Melting Point: 104-108 °C(lit.)
• Boiling Point: 272℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.312
• Vapor Pressure: 0.00309mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• PKA: 4.63±0.10(Predicted)
• CAS DataBase Reference: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID(134672-70-1)
• EPA Substance Registry System: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID(134672-70-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-39-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 134672-70-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-(2,4-Difluorophenyl)propionic acid is utilized as a reagent in organic synthesis, specifically for its capacity to introduce a difluorophenyl moiety into different molecules. This addition can alter the chemical properties of the target molecules, making them suitable for further reactions or applications.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-(2,4-difluorophenyl)propionic acid serves as an intermediate in the synthesis of various drugs. Its incorporation into drug molecules can enhance their efficacy, stability, or bioavailability, contributing to the development of new therapeutic agents.
Used in Agrochemical Production:
3-(2,4-Difluorophenyl)propionic acid is also employed in the agrochemical sector, where it acts as an intermediate in the production of pesticides or other agricultural chemicals. The difluorophenyl group can impart specific properties to these compounds, such as increased effectiveness against pests or improved environmental stability.
Overall, 3-(2,4-difluorophenyl)propionic acid is a versatile chemical with applications in various industries, including organic synthesis, pharmaceuticals, and agrochemicals, due to its ability to modify the properties of other molecules and serve as a key intermediate in the production of various compounds.

InChI:InChI=1/C9H8F2O2/c10-7-3-1-6(8(11)5-7)2-4-9(12)13/h1,3,5H,2,4H2,(H,12,13)

Upstream product

• 94977-52-3 2,4-Difluorocinnamic acid 
• 134672-69-8 ethyl 3-(2,4-difluorophenyl)propanoate 

Downstream Products

• 162549-39-5 3-(2,4-difluorophenyl)propionyl chloride 
• 849488-10-4 (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 924623-91-6 N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-3-(2,4-difluoro-phenyl)-propionamide 
• 1057678-43-9 1-(3-bromopropyl)-2,4-difluorobenzene 
• 1065584-71-5 1-(4-(2-(5-amino-2-(furan-2-yl)-7H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)-3-(2,4-difluorophenyl)propan-1-one 
• 162548-73-4 4,6-difluoroindan-1-one 

Relevant articles and documents

3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.

ADENOSINE A2A RECEPTOR ANTAGONISTS

The present invention provides compounds of the formula wherein R1 and R2 have meaning as defined herein in the specification. The compounds of formula (I) are adenosine A2A receptor antagonists and, thus, may be employed

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity

The design of rigid cyclic analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and β-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17. Compound 17 also possesses potent antiinflammatory and analgesic activity. This paper describes the synthesis and the muscle relaxant, antiinflammatory, and analgesic structure-activity relationships of 17 and 67 of its analogues. Compound 17 has been taken into phase I clinical trials.

Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives

Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about ?5 to about +100° C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.

Bicyclic amide derivatives and their use as muscle relaxants

Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.

Bicyclic amide derivatives and their use as muscle relaxants

Novel compounds of formula (I) STR1 wherein R1, R2, R3 and R4 are each selected from hydrogen and fluoro and at least one and not more than two is fluoro; R5 is selected from hydrogen and C1 -C4 alkyl; R6 is selected from hydrogen, C1 -C4 ally and hydroxy; or R5 and R6 together with the ring carbon form a carbonyl group; R7 is selected from hydrogen and hydroxy, R8 and R9 are each selected from hydrogen, C1 -C4 alkyl and cyclo(C3 or C4) alkyl or together with the nitrogen form a morpholino group; and X is selected from a bond, methylene and --O-- and is always a bond or --O-- when any of R5, R6 and R7 is other than hydrogen and is always a bond when R5 and R6 together with the ring carbon form a carbonyl group; and their salts and solvates have a number of uses as central muscle relaxants. In particular, treatment of conditions associated with abnormally raised skeletal muscle tone. They are of special value in the relaxation of skeletal muscle in spastic, hypertonic and hyperkinetic conditions.

Novel nitrogen-containing titanocenes, and the use thereof

Titanocenes of the formula I STR1 in which R1 are cyclopentadienyl? groups and R2 and R3 are aromatic radicals which are substituted in both ortho-positions by fluorine and, in addition, are substituted by a pyrrylalkyl group, amidoalkyl group or imidoalkyl group, are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds.